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Do retinoids increase the risk of fracture?

Do retinoids increase the risk of fracture?

Studies have shown that a high intake of vitamin A in the diet, whether through food or supplements can have damaging effects on the skeleton.

Namely, decrease in mineral density and fracture. As a result, concerns have been raised about retinoids, the chemical compounds derived from vitamin A used to treat skin conditions such as acne and psoriasis.

Danish researchers recently conducted a comparative study on hundreds of thousands of people, some of whom had already had fractures and others not, while determining the possible use of oral or topical retinoids by each nobody.

Their results, published in the Archives of Dermatology, show that neither oral nor topical use of retinoids, such as isotretinoin or acitretin, has a negative effect on the patient’s bones. . In addition, increased doses and long-term use of retinoids were not associated with a high risk of fractures.

“Neither acne nor psoriasis, indications of a systemic treatment with vitamin A analogues [retinoids], do not influence the risk of fracture, ”the researchers wrote. “So it looks like vitamin A analogs are safe for fractures, even at very high doses.”

Despite these results, it makes sense for retinoid users to include enough vitamin D and calcium in their diet.

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